PPIs Enhance risk of hip fracture

Postmenopausal females who repeatedly use proton pump motor inhibitors (PPIs) are at improved risk of struggling hip fracture, a considerable US study implies.

Data on almost 80,000 women confirmed those who utilized PPIs over at least two years have been 35 per cent more likely to suffer hip fractures compared to non-users, over an eight-year period.

This risk increased to more than 50 per cent if they were also current or former smokers, found the study, which has been published in the BMJ.

The chance of hip fracture improved with even longer period of PPI use. However, the effect vanished in less than two years of discontinuing PPIs.

The clinicians suggested PPIs could boost fracture threat by reducing gastric acid forming, thus impacting assimilation of calcium. Smoking had also been revealed to inhibit calcium absorption, they pointed out.

“Smoking and PPIs could have a synergistic effect on fracture threat mediated by impaired calcium absorption,” provided the researchers, from Massachusetts General Hospital and Harvard Medicinal School.

“In companion, experimental research has said that both PPIs and smoking effect osteoclast operate, perhaps recommending a mutual negative effect on further bones remodeling.

In 2000, a few 6.7 per cent of women have been regularly utilizing PPIs, increasing to almost 20 per cent in 2008. There have been 893 incident hip fractures during the study period, which generally ran from 2000 to 2008. Individuals have been drawn coming from the Nurses’ Health Study and were actually followed-up biennially.