In affected individuals with brain aneurysm, clazosentan - an experimental drug reductions the possibility of blood vessel spasm, according to the research.
In affected individuals with a subarachnoid hemorrhage, despite the burst weak link in the vessel closes, irritation out of your initial bleeding may cause blood vessels to constrict, cutting off regular blood supply and leading to even more brain damage. This can be often called a "second stroke." The vessel constraint is called angiographic vasospasm (VSP) that may occur around to 14 days after aneurysm rupture.
"We do not have highly effective treatments for this complication," said R. Loch Macdonald, M.D., study lead author and head of neurosurgery at St. Michael's Hospital, University of Toronto in Ontario, Canada. "The therapy in use now is very expensive and risky and doesn't work well, and about half of many patients undergo permanent concerns from it."
Researchers split patients into three groups, each given probably a placebo, 5 mg clazosentan or 15 mg clazosentan. They halted CONSCIOUS-3 prematurely after affected individuals in CONSCIOUS-2 (an attempt of patients whose ruptured aneurysm appeared to be secured by coiling), which generally ran simultaneously, showed no benefit from the medication.
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